منابع مشابه
Shear stress regulates endothelial microparticle release.
RATIONALE Endothelial activation and apoptosis release membrane-shed microparticles (EMP) that emerge as important biological effectors. OBJECTIVE Because laminar shear stress (SS) is a major physiological regulator of endothelial survival, we tested the hypothesis that SS regulates EMP release. METHODS AND RESULTS EMP levels were quantified by flow cytometry in medium of endothelial cells ...
متن کاملDeciphering the endothelial shear stress sensor.
The single nonmotile primary cilium, protruding several microns from the apical surface, contains cytoskeletal elements in a specific fashion. It consists of 9 circularly arranged microtubule doublets, as revealed by transmission electron microscopy,1 but lacks the central ones characteristic for motile cilia and flagellae. The primary cilium is anchored to the basal body and is thereby connect...
متن کاملFunctional Roles of Shear Stress in Vascular Endothelial Cells
Endothelial cells play remarkable roles in regulating vascular function in health and disease. Meanwhile, shear stress, which is created due to the friction of the flowing blood on the endothelium of the arterial wall, is critical for vascular homeostasis. Here, the shear stress patterns and its effect on gene expression and vascular function are reviewed.
متن کاملShear stress-initiated signaling and its regulation of endothelial function.
Atherosclerosis develops preferentially at branches and curvatures of the arterial tree, where blood flow pattern is disturbed rather than being laminar, and wall shear stress has an irregular distribution without defined directions. The endothelium in the atherosusceptible regions, in comparison to that in atheroresistant regions, shows activation of proproliferative and proinflammatory gene e...
متن کاملRegulation of endothelial connexin40 expression by shear stress.
Endothelial connexin (Cx)40 plays an important role in signal propagation along blood vessel walls, modulating vessel diameter and thereby blood flow. Blood flow, in turn, has been shown to alter endothelial Cx40 expression. However, the timing and shear stress dependence of this relationship have remained unclear, as have the signal transduction pathways involved and the functional implication...
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ژورنال
عنوان ژورنال: Circulation: Cardiovascular Imaging
سال: 2010
ISSN: 1941-9651,1942-0080
DOI: 10.1161/circimaging.109.916304